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  • Brian Nahed blood based biomarker 1

    Drs. Brian Nahed and Shannon Stott are working to develop the first blood based test for patients with brain tumors.

  • Brian Nahed blood based biomarker 2
  • Brian Nahed blood based biomarker 3
  • Brian Nahed blood based biomarker 4

Mission

The MGH Blood Based Biomarker lab is focused on developing the first blood based test for patients with brain tumors.

Advances in neurosurgery, chemotherapy, and radiation therapy have led to exciting breakthroughs in the care of patients however, there remains no real-time test to monitor a patient’s response to therapy and detecting recurrence of disease is limited to MRIs.  Our laboratory strives to offer patients and their physicians a simple blood test which will provide the ability to diagnose and monitor brain tumors in real-time.  Using technology developed at the MGH Cancer Center, Drs. Brian Nahed and Shannon Stott have developed the first device to identify and analyze circulating tumor cells in brain tumor patients and extra-cellular vesicles (exosomes).  Together, Nahed and Stott are developing the only comprehensive blood based test to diagnose, characterize, and monitor patients with brain tumors.

Dr. Brian Nahed is a neurosurgeon specializing in brain tumors with a specific focus on gliomas (low and high grade), glioblastoma, meningiomas and metastatic cancers.

Dr. Shannon Stott is a biomedical engineer specializing in the development of blood based captured devices and the identification and capture of circulating tumor cells and extra-cellular vesicles in cancer.

Intraoperative imaging
Using sophisticated MRI-based diffusion tensor imaging, Dr. Brian Nahed and his colleagues study subcortical fibers tracts to plan a surgical approach, which is stimulated intraoperatively to confirm avoidance of the tracts and to test and preserve function. Dr. Nahed uses multi-modality intraoperative imaging and intraoperative brain mapping including intraoperative ultrasound to detect extent of resection of infiltrative brain tumors, and intraoperative magnetic resonance imaging to accurately detect extent of resection in real-time using the ultrasound.

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Precision surgery
Using sophisticated MRI-based diffusion tensor imaging, Dr. Brian Nahed and his colleagues study subcortical fibers tracts to plan a surgical approach, which is stimulated intraoperatively to confirm avoidance of the tracts and to test and preserve function.

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Research
As a surgeon-scientist, Dr. Brian Nahed’s research aims to develop the first blood-based test to diagnose and monitor brain tumor patients.

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Research

Blood Based Test for Brain Tumors

Drs. Brian Nahed and Shannon Stott, together with a team comprised of biomedical engineers, cancer biologists, and clinicians, are working to develop the first blood based test for patients with brain tumors. Their recent success in capturing circulating tumor cells and exosomes in brain tumor patients serves as the catalyst for their combined effort to develop a comprehensive blood based tests for brain tumors. Nahed and Stott are currently enrolling patients into their translational research study at the MGH.

Publications

Dr. Brian Nahed has authored 104 peer-reviewed publications. A complete list of all his publications can be found on PubMed. He has presented his work at the American Association of Neurological Surgeons, Congress of Neurological Surgeons, Society for Neurooncology, and Council for State Neurosurgical Societies.

For a complete list please visit PubMed.

Recent publications from the Nahed / Stott laboratory

Babu, MA, Nahed, BV, Heary, RF. Commentary: Prescription Drug Monitoring Programs and the Neurosurgeon: Impact on Workflow and Overall Perceptions. Neurosurgery. 2018; :. doi: 10.1093/neuros/nyy314. PubMed PMID:30011043

Lee, DK, Fedorenko, E, Simon, MV, Curry, WT, Nahed, BV, Cahill, DP et al.. Neural encoding and production of functional morphemes in the posterior temporal lobe. Nat Commun. 2018;9 (1):1877. doi: 10.1038/s41467-018-04235-3. PubMed PMID:29760465 PubMed Central PMC5951905

Zachariah, M, Oliveira-Costa, JP, Carter, B, Stott, SL, Nahed, BV. Blood-Based Biomarkers for the Diagnosis and Monitoring of Gliomas. Neuro-oncology. 2018; :. doi: 10.1093/neuonc/noy074. PubMed PMID:29746665

Dabek, RJ, Baletic, N, McUmber, H, Nahed, B, Haynes, A, Eberlin, KR et al.. Development of a primary melanoma in situ within a full-thickness skin graft overlying a free muscle flap: a case report. Case Reports Plast Surg Hand Surg. 2018;5 (1):23-26. doi: 10.1080/23320885.2018.1452615. PubMed PMID:29707609 PubMed Central PMC5917313

Reátegui, E, van der Vos, KE, Lai, CP, Zeinali, M, Atai, NA, Aldikacti, B et al.. Engineered nanointerfaces for microfluidic isolation and molecular profiling of tumor-specific extracellular vesicles. Nat Commun. 2018;9 (1):175. doi: 10.1038/s41467-017-02261-1. PubMed PMID:29330365 PubMed Central PMC5766611

Shankar, GM, Balaj, L, Stott, SL, Nahed, B, Carter, BS. Liquid biopsy for brain tumors. Expert Rev. Mol. Diagn.. 2017;17 (10):943-947. doi: 10.1080/14737159.2017.1374854. PubMed PMID:28875730 PubMed Central PMC5856481

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