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Mission

Advances in neurosurgery, chemotherapy, and radiation therapy have led to exciting breakthroughs in the care of patients however, there remains no real-time test to monitor a patient’s response to therapy and detecting recurrence of disease is limited to MRIs.  Our laboratory strives to offer patients and their physicians a simple blood test which will provide the ability to diagnose and monitor brain tumors in real-time.  Using technology developed at the MGH Cancer Center, Drs. Brian Nahed and Shannon Stott have developed the first device to identify and analyze circulating tumor cells in brain tumor patients and extra-cellular vesicles (exosomes).  Together, Nahed and Stott are developing the only comprehensive blood based test to diagnose, characterize, and monitor patients with brain tumors.

Dr. Brian Nahed is a neurosurgeon specializing in brain tumors with a specific focus on gliomas (low and high grade), glioblastoma, meningiomas and metastatic cancers.

Dr. Shannon Stott is a biomedical engineer specializing in the development of blood based captured devices and the identification and capture of circulating tumor cells and extra-cellular vesicles in cancer.

Intraoperative imaging
Using sophisticated MRI-based diffusion tensor imaging, Dr. Brian Nahed and his colleagues study subcortical fibers tracts to plan a surgical approach, which is stimulated intraoperatively to confirm avoidance of the tracts and to test and preserve function. Dr. Nahed uses multi-modality intraoperative imaging and intraoperative brain mapping including intraoperative ultrasound to detect extent of resection of infiltrative brain tumors, and intraoperative magnetic resonance imaging to accurately detect extent of resection in real-time using the ultrasound.

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Precision surgery
Using sophisticated MRI-based diffusion tensor imaging, Dr. Brian Nahed and his colleagues study subcortical fibers tracts to plan a surgical approach, which is stimulated intraoperatively to confirm avoidance of the tracts and to test and preserve function.

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Research
As a surgeon-scientist, Dr. Brian Nahed’s research aims to develop the first blood-based test to diagnose and monitor brain tumor patients.

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November 2, 2016 Comments Off on Mission

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